Zstandard's long range mode works wonders for genome sequences without newlines September 12, 2025 First released with Zstandard 1.3.2 in 2017, the --long range match finder increases the compressor’s search window to at least 128MiB, improving deduplication inside large files. This optional feature had substantial performance overheads at launch, but various optimisations have since brought its performance within shooting distance of Zstandard’s fast defaults. As a fan of Zstandard’s speed and efficiency, I hoped that --long might improve genome compression and bridge the chasm between fast general-purpose compressors with low compression ratios (CRs), and much slower specialist DNA sequence compressors capable of far higher CRs. Grace Blackwell’s 2.6Tbp 661k dataset is a classic choice for benchmarking methods in microbial genomics. Comprising many similar DNA sequences, its 661,405 bacterial genome assemblies in FASTA text format are very compressible. Karel Břinda’s specialist MiniPhy approach takes this dataset from 2.46TiB to just 27GiB (CR: 91) by clustering and compressing similar genomes together. By comparison, naive Zstandard with default parameters compresses an order of magnitude faster, but achieves a CR of just 3. I was initially underwhelmed by --long ’s modest reduction of the 661k dataset from 777GiB (Zstandard default) to 641GiB (CR: 4). I speculated that this poor performance might be caused by the newline bytes ( 0x0A ) punctuating every 60 characters of sequence, breaking the hashes used for long range pattern matching. Indeed, removing within-record newlines using seqtk seq -l 0 tripled zstd --long ’s CR to 11, yielding a 232GiB file while increasing compression time by only ~20% over Zstandard defaults. Increasing the window size to the 2GiB maximum on 64bit systems using --long=31 tripled CR again to 31, yielding an 80GiB file, increasing compression time by ~80% over Zstandard defaults. Using larger-than-default window sizes has the drawback of requiring that the same --long=xx argument be passed during decompression reducing compatibility somewhat. Results naturally vary between datasets, but given its low overheads, --long is often worth a try. In this case zstd --long=31 achieved a compression ratio within an order of magnitude of slower state-of-the-art methods, representing a useful compromise. Just remember to remove within-record newlines from your fasta files beforehand. 661k, single FASTA file Compression Line length Size (GiB) Ratio Uncompressed 60 2460 1 Gzip (pigz) 60 751 3.3 Zstandard 60 777 3.2 Zstandard --long 60 641 3.8 Zstandard --long 0 (infinite) 232 11 Zstandard --long=31 0 (infinite) 80 31