The science of poop has yielded some fascinating results, but the latest installment in this beat may be the most astounding yet. After decades of noticing but generally not understanding why reptiles “pee” crystals, researchers finally believe they have the answer.
In a Journal of the American Chemical Society paper published today, a team of organic chemists and herpetologists describes their investigation of pee crystals from more than 20 reptile species. Simply, reptiles package up excess nitrogen into tiny, textured spheres consisting of even smaller microcrystals. These microscopic processes offer an evolutionary advantage for snakes, in addition to hinting at some broader implications for human health, according to the researchers.
The science of urine
The project began with an odd inquiry that Jennifer Swift, a crystallographer at Georgetown University, received from herpetologist Gordon Schuett. Specifically, Schuett wanted to know why, despite feeding the reptiles under his care the same food and water, there was such a weird variety in their pee crystals.
“What he observed was that among all of the critters that he had in his museum, some of them would excrete urates that dry to a rock-hard mass, and some of them would dry to something that looked like dust,” Swift, the study’s senior author, told Gizmodo in a phone call. “He asked if I knew what was going on, and I said, ‘I have no idea. Why don’t you send me some samples?’”
Swift’s focus thus far had been the accumulation of uric acid crystals in humans, which leads to serious health issues such as gout or kidney stones. Uric acid is one of three main forms produced by animals while breaking down excess nitrogen in their bodies. We mammals pass excess nitrogen as urea, which, along with lots of water, becomes urine.
On the other hand, reptiles and avians (both descended from dinosaurs) excrete nitrogen as solid uric acid, which researchers believe could have allowed the animals to preserve water in dry climates.
Cracking the mystery of “pee” crystals
Given the pesky implications of solid uric acid in humans, researchers did clock the potential benefits in learning how reptiles appeared to pass these crystals without too much trouble. But the few attempts to properly describe the molecular mechanisms in play weren’t very successful, according to Swift.
“Because we didn’t know what we were dealing with, either, we cobbled together literally every analytical method we could under the Sun, and studied it in every direction that we could,” she said.
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