While "there's not a ton of evidence out there to firmly say one supplement is going to help you over another," Mysore said, glucosamine likely has the most evidence backing its use. Glucosamine naturally occurs in our bodies -- it's in your cartilage and helps your joints function. A glucosamine supplement is believed to help with arthritis in that it can bring down some of the pain brought on by osteoarthritis or rheumatoid arthritis. According to the Arthritis Foundation, glucosamine is commonly sold in combination with chondroitin as a single supplement, and both are two of the most commonly used supplements for arthritis.
Mysore said people with shellfish and iodine allergies need to be careful about taking this supplement, as it's often made from shellfish, and that it could also affect people with asthma. It has the potential to cause side effects like nausea and heartburn, and there's also a risk of interaction with blood thinners or anticoagulant medications that could cause bleeding issues. Talk with your doctor or dietician before adding it to your diet.