A tiny wireless chip placed at the back of the eye, combined with a pair of advanced smart glasses, has partially restored vision to people suffering from an advanced form of age-related macular degeneration. In a clinical study led by Stanford Medicine and international collaborators, 27 of the 32 participants regained the ability to read within a year of receiving the implant.
With the help of digital features such as adjustable zoom and enhanced contrast, some participants achieved visual sharpness comparable to 20/42 vision.
The study's findings were published on Oct. 20 in the New England Journal of Medicine.
A Milestone in Restoring Functional Vision
The implant, named PRIMA and developed at Stanford Medicine, is the first prosthetic eye device to restore usable vision to individuals with otherwise untreatable vision loss. The technology enables patients to recognize shapes and patterns, a level of vision known as form vision.
"All previous attempts to provide vision with prosthetic devices resulted in basically light sensitivity, not really form vision," said Daniel Palanker, PhD, a professor of ophthalmology and a co-senior author of the paper. "We are the first to provide form vision."
The research was co-led by José-Alain Sahel, MD, professor of ophthalmology at the University of Pittsburgh School of Medicine, with Frank Holz, MD, of the University of Bonn in Germany, serving as lead author.
How the PRIMA System Works
The system includes two main parts: a small camera attached to a pair of glasses and a wireless chip implanted in the retina. The camera captures visual information and projects it through infrared light to the implant, which converts it into electrical signals. These signals substitute for the damaged photoreceptors that normally detect light and send visual data to the brain.
The PRIMA project represents decades of scientific effort, involving numerous prototypes, animal testing, and an initial human trial.
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