He Jiankui, the Chinese scientist who served three years in prison after creating the world's first gene-edited babies in 2018, is now preparing for another attempt at germline editing -- this time to prevent Alzheimer's disease. In an interview, He said he has established an independent lab in south Beijing and raised $7 million from private donors to fund research into introducing a protective genetic mutation found in Icelandic populations.
The three girls born from his original experiment are now in primary school and healthy, according to He. Since germline editing remains banned in China, He said he plans to conduct future human trials in South Africa and has already spoken with contacts there. He estimates he needs two more years to complete mouse and monkey studies before seeking regulatory approval abroad. He said his lab is developing techniques to make 12 simultaneous genetic edits in a single embryo, targeting genes associated with cancer, cardiovascular disease, HIV, and other conditions. He is currently working on human cell lines and has not yet begun embryo experiments.
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