RNA interference and nanomedicine team up to fight dangerous fungal infections

This article has been reviewed according to Science X's editorial process and policies . Editors have highlighted the following attributes while ensuring the content's credibility: A digital cover illustration for the journal Nanoscale (2025, Volume 17, Page 7002). Credit: Andreas Beilhack, created with Procreate Fungal infections are on the rise globally. According to a study by the Manchester Fungal Infection Group, in 2022, approximately 6.5 million people were infected by a pathogenic fungus, and about 3.8 million died as a result—nearly twice as many as in 2012. Even with medications, known as antifungals, the mortality rate for invasive infections caused by the mold Aspergillus fumigatus is as high as 85%. As resistant fungal strains increase, treatment becomes more difficult, and new therapies are urgently needed. A research team from Würzburg has succeeded for the first time in packaging small interfering RNAs (siRNAs) with Amphotericin B (AmB) in anionic liposomes to specif ... Read full article.