The short, strange history of gene de-extinction

To be sure, there is a long way to go. The mice Colossal created include several genetic changes previously known to make mice furry or long-haired. That is, the changes were mammoth-like, but not from a mammoth. In fact, only a single letter of uniquely mammoth DNA was added to the mice. Because this idea is so new and attracting so much attention, I decided it would be useful to create a record of previous attempts to add extinct DNA to living organisms. And since the technology doesn’t have a name, let’s give it one: “chronogenics.” “Examples are exceptionally few currently,” says Ben Novak, lead scientist at Revive & Restore, an organization that applies genetic technology to conservation efforts. Novak helped me track down examples, and I also got ideas from Harvard geneticist George Church—who originally envisioned the mammoth project—as well as Beth Shapiro, lead scientist at Colossal. The starting point for chronogenics appears to be in 2004. That year, US scientists reporte ... Read full article.