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Zorgdomein Integration: A Guide to Secure .NET and Azure Architecture

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In the world of modern healthcare IT, “interoperability” is often treated as a buzzword. But for CTOs and Engineering Managers operating in highly regulated European markets, interoperability is a high-stakes engineering challenge.

Recently, I led a project for a Dutch healthcare client that required a robust integration with Zorgdomein, the central gateway for healthcare communication in the Netherlands. The mission: enable bidirectional exchange of patient documents and treatment information between a proprietary SaaS platform and a network of hospitals.

Success in this environment is not determined by how fast you can write code; it’s determined by how you architect for security, compliance, and data integrity. In this article, I’ll break down the specific technical hurdles we overcame, from mTLS handshaking to FHIR mapping.

The Gateway Challenge: Understanding the “Double-Lock” Security

Integrating with a national healthcare portal like Zorgdomein requires more than just an API key. It demands a “Double-Lock” authentication mechanism: Mutual TLS (mTLS) for the transport layer and JWT (JSON Web Tokens) for the application layer.

The mTLS Handshake in IIS

For our Server-to-Server (S2S) communication, establishing a secure channel meant configuring IIS for certificate-based authentication. This is where most enterprise integrations face their first roadblock.

In a standard web environment, the server identifies itself to the client. In mTLS, the client must also present a valid, Zorgdomein-trusted certificate. Configuring this in a .NET environment involves:

IIS SSL Settings: Moving beyond “Ignore” to “Negotiate” or “Require” certificates.

The Trust Chain: Ensuring the server has the correct Root and Intermediate CAs installed to validate the incoming certificate without manually bypassing security checks.

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