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Study finds thousands of non-genetic protein variants expand human proteome diversity

Researchers analyzed proteogenomic data from 29 healthy human tissues and identified over 13,900 localized protein variants, including 7,215 unique amino acid substitutions existing alongside standard reference proteins. Many of these variants arise not from DNA mutations but from translational errors, with their abundance patterns linked to population allele frequencies and specific patterns emerging under amino acid starvation in cancer cell lines.

Signal to adopt zero-knowledge proofs for phone-number-free registration

Signal is moving toward letting users register accounts without providing a phone number, using zero-knowledge proof cryptography to verify accounts without exposing identifying data. The technology mirrors methods Signal already uses for donation badges and group membership, where proofs confirm status without revealing which specific badge or group is involved.

OpenAI halts new sign-ups for $200 Pro plan amid Astra surge

OpenAI has temporarily disabled new subscriptions to its $200-per-month Pro plan after unprecedented demand for its Astra model overwhelmed its infrastructure. Product lead Thibault Sottiaux said the Pro tier strains systems the most, so the company chose to pause it rather than degrade service for existing users. Other offerings, including API access and the Go and Plus plans, remain open to new customers.

ABF substrate supply chain faces bottleneck as AI chip demand surges

Ajinomoto build-up film, the insulating material used in nearly every high-end CPU, GPU, and AI accelerator package, is supplied almost entirely by one Japanese company that controls over 95% of the global market. As AI data centers scale into the gigawatt era with millions of accelerators needed, this narrow supply chain of substrate makers and a single film source is becoming a critical constraint on chip production.

Tracker: Nine major streaming subscriptions now cost $702 more per year than in 2021

An independent pricing tracker compiled monthly rates for nine flagship streaming tiers—Netflix, Disney+, Hulu, HBO Max, Apple TV+, Paramount+, Peacock, YouTube Premium and Spotify—comparing March 2021 to today. The combined monthly cost for the same services rose from $95.91 to $154.41, a 61% jump equal to $702 more annually, without any downgrades or cancellations factored in.

Anthropic sued over Claude Max subscription usage claims

A group of Claude users filed a class-action lawsuit against Anthropic on September 8, alleging the company misled subscribers about usage limits on its $100 and $200 Max plans. The suit contends Anthropic advertised 5x and 20x more usage than the Pro tier without disclosing that weekly caps, added months after Max launched in April 2025, sharply reduce the real benefit compared to the marketed multiplier.

Google tests letting Gemini overlay hand off tasks to Spark agent without opening app

Android Authority found code in a beta build of the Google app (version 17.56.14) suggesting Gemini's floating overlay could soon let users assign tasks to Spark, Google's autonomous AI agent, without launching the full Gemini interface. The same handover option is also being tested in the main Gemini app, alongside a possible model-switching shortcut in the overlay.

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