RNA structure prediction is hard. How much does that matter?
Note: I am not an expert in RNA structure, and am extremely grateful to Connor Stephens, Rishabh Anand, Ramya Rangan, and Chaitanya K. Joshi—all of whom are actual, bonafide experts—for their incredibly detailed comments on earlier drafts of this essay. All mistakes are, of course mine, and this essay should not be trusted to function as anything more than entertainment. Do your own research! Introduction One thing I’ve always wanted to write was ‘a primer to RNA structure modeling’. I know li