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Towards intelligent and miniaturized drug delivery devices

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Why This Matters

Advances in miniaturized and intelligent drug delivery devices are transforming personalized medicine by enabling precise, controlled, and minimally invasive treatments. These innovations hold promise for improving patient adherence, reducing side effects, and expanding treatment options across various medical fields.

Key Takeaways

Langer, R. & Tirrell, D. A. Designing materials for biology and medicine. Nature 428, 487–492 (2004).

Baryakova, T. H., Pogostin, B. H., Langer, R. & McHugh, K. J. Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems. Nat. Rev. Drug Discov. 22, 387–409 (2023).

Farra, R. et al. First-in-human testing of a wirelessly controlled drug delivery microchip. Sci. Transl. Med. 4, 122ra121 (2012). This paper reports on the first clinical trial of an implantable microchip-based drug delivery device.

Yu, J. et al. Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery. Proc. Natl Acad. Sci. USA 112, 8260–8265 (2015). This paper describes a glucose-responsive transdermal device for regulation of insulin release.

Arrick, G. et al. Cephalopod-inspired jetting devices for gastrointestinal drug delivery. Nature 636, 481–487 (2024). This study developed and evaluated microjet delivery systems that can deliver jets in axial and radial directions into tissue.

Shi, J. et al. Active biointegrated living electronics for managing inflammation. Science 384, 1023–1030 (2024). This paper reports a biointegrated living device that wirelessly records electrical signals from the skin surface and improves disease treatment in a mouse model of psoriasis.

Yin, D. et al. A battery-free nanofluidic intracellular delivery patch for internal organs. Nature 642, 1051–1061 (2025). This paper describes a chipless, soft nanofluidic intracellular delivery patch that provides enhanced and customized delivery of payloads in targeted internal organs.

Zheng, M., Sheng, T., Yu, J., Gu, Z. & Xu, C. Microneedle biomedical devices. Nat. Rev. Bioeng. 2, 324–342 (2024).

Paci, M. M. et al. Smart closed-loop drug delivery systems. Nat. Rev. Bioeng. 3, 816–834 (2025).

Mirvakili, S. M. & Langer, R. Wireless on-demand drug delivery. Nat. Electron. 4, 464–477 (2021).

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