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A mechanism for adaptive genome regulation in cancer

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Why This Matters

This research highlights a novel mechanism for adaptive genome regulation in cancer, emphasizing how cancer cells can dynamically alter their gene expression states. Understanding these mechanisms is crucial for developing targeted therapies and improving patient outcomes, as it sheds light on tumor heterogeneity and evolution. This knowledge can lead to more precise interventions that disrupt cancer's ability to adapt and survive.

Key Takeaways

Llinás, R. R. The contribution of Santiago Ramón y Cajal to functional neuroscience. Nat. Rev. Neurosci. 4, 77–80 (2003).

McCulloch, E. A. & Till, J. E. Perspectives on the properties of stem cells. Nat. Med. 11, 1026–1028 (2005).

Kumar, T. et al. A spatially resolved single-cell genomic atlas of the adult human breast. Nature 620, 181–191 (2023).

Sikkema, L. et al. An integrated cell atlas of the lung in health and disease. Nat. Med. 29, 1563–1577 (2023).

Barkley, D. et al. Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment. Nat. Genet. 54, 1192–1201 (2022).

Gavish, A. et al. Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours. Nature 618, 598–606 (2023). The Barkley et al. and Gavish et al. studies define meta programs of gene expression across many tumour types, showing that cancer cell states tend to be shared across tumours.

Gargiulo, G., Serresi, M. & Marine, J.-C. Cell states in cancer: drivers, passengers, and trailers. Cancer Discov. 14, 610–614 (2024).

Zeng, H. What is a cell type and how to define it? Cell 185, 2739–2755 (2022).

Velten, L. et al. Human haematopoietic stem cell lineage commitment is a continuous process. Nat. Cell Biol. 19, 271–281 (2017).

Pastushenko, I. et al. Identification of the tumour transition states occurring during EMT. Nature 556, 463–468 (2018).

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