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Glycerol-driven TNAP activation in thermogenesis and mineralization

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Why This Matters

This research highlights the crucial role of glycerol-driven TNAP activation in regulating thermogenesis and mineralization, offering new insights into metabolic processes and potential therapeutic targets for metabolic disorders. Understanding these mechanisms can lead to innovative treatments for obesity, osteoporosis, and related conditions, benefiting both the tech industry involved in biomedical innovations and consumers seeking improved health solutions.

Key Takeaways

Millan, J. L. Alkaline phosphatases: structure, substrate specificity and functional relatedness to other members of a large superfamily of enzymes. Purinergic Signal. 2, 335–341 (2006).

Rahbani, J. F. et al. ADRA1A–G αq signalling potentiates adipocyte thermogenesis through CKB and TNAP. Nat. Metab. 4, 1459–1473 (2022).

Sun, Y. et al. Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine. Nature 593, 580–585 (2021).

Reznikov, N. et al. Biological stenciling of mineralization in the skeleton: local enzymatic removal of inhibitors in the extracellular matrix. Bone 138, 115447 (2020).

Narisawa, S., Frohlander, N. & Millan, J. L. Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia. Dev. Dyn. 208, 432–446 (1997).

Millan, J. L. & Whyte, M. P. Alkaline phosphatase and hypophosphatasia. Calcif. Tissue Int. 98, 398–416 (2016).

Bunk, J. et al. The futile creatine cycle powers UCP1-independent thermogenesis in classical BAT. Nat. Commun. 16, 3221 (2025).

Bunk, J. et al. Creatine kinase B mediates UCP1-independent beige fat thermogenesis via the futile creatine cycle in mice. Mol. Metab. 98, 102193 (2025).

Rahbani, J. F. et al. Creatine kinase B controls futile creatine cycling in thermogenic fat. Nature 590, 480–485 (2021).

Hsieh, A. C. & Carlson, L. D. Role of adrenaline and noradrenaline in chemical regulation of heat production. Am. J. Physiol. 190, 243–246 (1957).

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