Substrate selectivity of the human RNA m⁵C methyltransferase NSUN2

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This research advances understanding of the substrate specificity of human NSUN2, a key RNA methyltransferase involved in epigenetic regulation. By detailing the cloning, purification, and activity of NSUN2, it provides foundational insights that could inform targeted therapies and RNA modification technologies in the biotech industry. Such knowledge enhances our ability to manipulate RNA modifications for therapeutic and diagnostic applications, benefiting both industry innovation and patient outcomes.

• NSUN2's substrate selectivity is crucial for its role in RNA modification.
• The study provides detailed protocols for cloning and purifying NSUN2 and related complexes.
• Understanding NSUN2 can lead to new therapeutic strategies targeting RNA methylation.