GoKawiilWiebach, V. et al. The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides. Nat. Chem. Biol. 14, 652–654 (2018).
Kayrouz, C. M., Zhang, Y., Pham, T. M. & Ju, K. S. Genome mining reveals the phosphonoalamide natural products and a new route in phosphonic acid biosynthesis. ACS Chem. Biol. 15, 1921–1929 (2020).
Tang, X. et al. Identification of thiotetronic acid antibiotic biosynthetic pathways by target-directed genome mining. ACS Chem. Biol. 10, 2841–2849 (2015).
Culp, E. J. et al. Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling. Nature 578, 582–587 (2020).
Culp, E. J. et al. ClpP inhibitors are produced by a widespread family of bacterial gene clusters. Nat. Microbiol. 7, 451–462 (2022).
Li, C. et al. Discovery of unusual dimeric piperazyl cyclopeptides encoded by a Lentzea flaviverrucosa DSM 44664 biosynthetic supercluster. Proc. Natl Acad. Sci. USA 119, e2117941119 (2022).
Morshed, M. T. et al. Chlorinated metabolites from Streptomyces sp. highlight the role of biosynthetic mosaics and superclusters in the evolution of chemical diversity. Org. Biomol. Chem. 19, 6147–6159 (2021).
Meyer, K. J. & Nodwell, J. R. Biology and applications of co-produced, synergistic antimicrobials from environmental bacteria. Nat. Microbiol. 6, 1118–1128 (2021).
Chen, X. & Li, B. Analysis of co-localized biosynthetic gene clusters identifies a membrane-permeabilizing natural product. J. Nat. Prod. 87, 1694–1703 (2024).
Alanjary, M. & Medema, M. H. Mining bacterial genomes to reveal secret synergy. J. Biol. Chem. 293, 19996–19997 (2018).
... continue reading