GoKawiilFor the very first time, biologists packed nonliving components into a cell-like membrane, piece by piece, and witnessed the bag of molecules start to behave like life. The lab-made synthetic cell grew, replicated its DNA, and divided, demonstrating the basic functions of a cell cycle.
It’s “an impressive step,” said Jack Szostak, who studies the origins of life at the University of Chicago and was not involved in the research. “I don’t know of any other effort to put together an artificial cell from biological components that has progressed so far.”
The cell is not alive by any definition. It can’t survive without constant deliveries of food and ribosomes, the machinery needed to make proteins. It has no defenses or a good waste removal system. But it’s the strongest demonstration yet that it is possible to generate life from nonlife, a goal that synthetic biologists have been chasing for decades.
“It’s a big step forward to this holy grail of making a living thing out of dead components,” said Sijbren Otto, a systems chemist at the Stratingh Institute for Chemistry in the Netherlands who was not involved in the work. “It’s not completely there yet, but it’s definitely getting quite close.”
Since these cells were pieced together from scratch, and all the molecular parts were crafted in the lab, scientists can tinker with the system and switch components in and out. “I have a blueprint, I have a full chemical ingredient list of every component,” said Kate Adamala, a synthetic biologist at the University of Minnesota who led the new study, which is not yet peer-reviewed. With such flexibility, this kind of synthetic cell could eventually be coaxed to create new materials, such as biofuels and drugs, and help researchers study disease.
The synthetic biologist Kate Adamala coaxed a cellular soup of nonliving biomolecules enclosed in a membrane to act somewhat like a living thing, even growing and dividing into daughter cells. Courtesy of Kate Adamala
It could also give scientists insight into some of their deepest existential questions: What is the minimum needed to sustain life? How could life start? What happens if we alter the biology that composes life on Earth today?
Or, as Adamala put it: “What else can biology do?”
Building Life
Some 4 billion years ago, a bunch of nonliving molecules got together to form the first protocells. They fed, grew, and divided. Then, over time, evolutionary processes emerged that let these cells change and diversify into many different types, decorating a barren world with all manner of strange beings. A purely chemical world blossomed into a biological one. Scientists cannot agree on how this shift from nonlife to life, or abiogenesis, happened, but some have turned their sights on trying it out for themselves in the lab.
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