Skip to content
Tech News
← Back to articles

Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase

read original more articles
Why This Matters

This research advances our understanding of the structural mechanisms and inhibition strategies for the Crimean–Congo hemorrhagic fever virus polymerase, a critical step toward developing effective antiviral therapies. Such insights are vital for the tech and healthcare industries aiming to combat viral outbreaks and improve diagnostic and treatment options for consumers. Ultimately, these findings could lead to more targeted antiviral drugs, enhancing global health security.

Key Takeaways

Ergönül, Ö. Crimean–Congo haemorrhagic fever. Lancet Infect. Dis. 6, 203–214 (2006).

Hawman, D. W. & Feldmann, H. Crimean–Congo haemorrhagic fever virus. Nat. Rev. Microbiol. 21, 463–477 (2023).

Feng, J. et al. Discovery of a macrocyclic influenza cap-dependent endonuclease inhibitor. J. Med. Chem. 67, 2570–2583 (2024).

Tchesnokov, E. P., Bailey-Elkin, B. A., Mark, B. L. & Götte, M. Independent inhibition of the polymerase and deubiquitinase activities of the Crimean–Congo hemorrhagic fever virus full-length L-protein. PLoS Negl. Trop. Dis. 14, e0008283 (2020).

Welch, S. R. et al. Identification of 2′-deoxy-2′-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 147, 91–99 (2017).

Muzammil, K. et al. Recent advances in Crimean-Congo hemorrhagic fever virus detection, treatment, and vaccination: overview of current status and challenges. Biol. Proced. Online 26, 20 (2024).

Fanelli, A. & Buonavoglia, D. Risk of Crimean Congo haemorrhagic fever virus (CCHFV) introduction and spread in CCHF-free countries in southern and Western Europe: a semi-quantitative risk assessment. One Health 13, 100290 (2021).

Malet, H., Williams, H. M., Cusack, S. & Rosenthal, M. The mechanism of genome replication and transcription in bunyaviruses. PLoS Pathog. 19, e1011060 (2023).

Gerlach, P., Malet, H., Cusack, S. & Reguera, J. Structural insights into bunyavirus replication and its regulation by the vRNA promoter. Cell 161, 1267–1279 (2015).

Arragain, B. et al. Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes. Nat. Commun. 11, 3590 (2020).

... continue reading