GoKawiilResearchers map 3D genome architecture of brain glial cells during human fetal cortex development
Scientists isolated cells from developing human cortex tissue between 15 and 24 weeks gestation, fixing and preserving them for later analysis. They then used fluorescence-activated cell sorting with antibody markers like SOX2, EOMES, HOPX, OLIG2 and PU.1 to separate specific cell populations, including radial glia and oligodendrocyte precursor/microglial cells, for downstream genomic study.
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Understanding the 3D genome organization of specific glial cell types during brain development could reveal how gene regulation shapes neural cell fate decisions in the womb. This kind of cell-type-specific epigenomic data is valuable for studying neurodevelopmental disorders that may originate from disrupted glial cell programming.
- Cells were sourced from human cortical tissue at gestational weeks 15 to 24
- FACS sorting used specific antibody markers to isolate radial glia and OPC/microglia populations
- The methodology enables detailed epigenomic profiling of distinct brain cell types during fetal development
Falcon 70 µm Cell Strainer (50-pack) — The protocol's filtering step relies on a 70- he exactly what these sterile nylon mesh strainers do — they snap onto standard 50 ml conical tubes and give you a clean single-cell suspension free of clumps. A lab-bench staple for anyone doing dissociation, FACS prep or single-cell sequencing work like the study describes.
See Falcon 70 µm Cell Strainer (50-pack) on Amazon → Affiliate link — we may earn a commission on purchases, at no extra cost to you. Product picked by AI based on this article; it is not a tested recommendation.Source: nature.com — Jones, 2026-09-02
Published there as: “3D epigenome of glial cell types in developing human cortex”
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