Researchers capture virus-like particle assembly in real time
Scientists led by Asor and colleagues developed a technique to directly observe individual virus-like particles as their protein shells form, publishing the results in Nature. The method allowed them to measure the speed and energy changes of shell assembly, something previously very difficult to track experimentally.
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Viral shells must assemble stably enough to protect genetic material yet be able to break apart to release it during infection, and understanding this balance has implications for antiviral drug design and engineering synthetic delivery systems. Directly measuring assembly kinetics gives researchers a clearer picture of the physical rules governing self-assembling biological structures, which could inform both medicine and nanotechnology.
- A new real-time imaging method tracks virus-like particle shell assembly at the individual particle level.
- The technique measures both the kinetics and energetics of the assembly process, addressing a long-standing experimental challenge.
- Findings could inform antiviral strategies and the design of synthetic self-assembling nanostructures.
Source: nature.com — Uetrecht, 2026-09-16
Published there as: “Virus-like particles observed assembling in real time”
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