GoKawiilResearchers identify DNA deletion behind orange cat coloring
Two independent research teams have traced orange fur in cats to a small missing DNA segment near a gene called Arhgap36, located on the X chromosome. Stanford geneticist Greg Barsh and colleagues found this 5-kilobase deletion present in every orange cat examined among 188 cats studied, and found orange-producing skin cells expressed 13 times more Arhgap36 RNA than non-orange cells.
GoKawiil's interpretation of the reporting above, not reported fact.
The finding resolves a genetics puzzle that had persisted for over 60 years, since orange coloring doesn't follow typical inheritance patterns seen in other mammals. Because the mutation sits on the X chromosome, it helps explain why most orange cats are male and why females with orange fur often display patchy calico or tortoiseshell patterns, according to the researchers.
- A 5-kilobase DNA deletion near the Arhgap36 gene causes orange fur in cats
- The deletion was found in all 145 orange and 6 calico/tortoiseshell cats studied, but not in 37 nonorange cats
- The gene's location on the X chromosome explains sex-linked differences in orange coloring patterns
GreenPet Orange Cat Breed DNA Test — This headline is basically a love letter to feline genetics, so why not explore your own orange cat's lineage and traits with a home cat DNA test kit? It's a fun way to dig into coat color genetics, breed ancestry, and health markers for the fiery-furred friend in your life. A perfect gift for any cat parent fascinated by the science behind their pet's unique look.
See GreenPet Orange Cat Breed DNA Test on Amazon → Affiliate link — we may earn a commission on purchases, at no extra cost to you. Product picked by AI based on this article; it is not a tested recommendation.Source: sciencealert.com — Tessa Koumoundouros, 2026-10-10
Published there as: “Secret of Orange Cats Revealed After 60-Year Search”
Read the original report → The summary and analysis above are GoKawiil's own, written from reporting by the source above. Facts and quotes belong to the original publisher.