NUS researcher applies freeze-casting technique to create tougher hydrogels
Xinyu Dong, a materials scientist at the National University of Singapore, is adapting freeze casting—a method traditionally used to build ceramic bone-repair scaffolds—to engineer hydrogels with improved structural properties. The technique involves freezing a water-based slurry in a controlled direction so ice crystals push material particles into an organized porous network, which is later preserved after the ice is removed. Dong began this work during her PhD in 2020 and has since extended the approach to aerogels and, in 2024, proposed a new variation of the freeze-casting process for hydrogels.
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Hydrogels are widely used in biomedical engineering because they resemble human tissue, but their fragility and sensitivity to dehydration or freezing have limited their clinical use. By borrowing a technique from ceramics manufacturing, Dong's work could lead to more durable, structurally tunable hydrogels suitable for implants or tissue engineering, though practical medical applications are not yet detailed in her reported findings.
- Freeze casting, normally used for ceramic bone scaffolds, is being adapted to improve hydrogel durability.
- Xinyu Dong's technique organizes material particles into structured pores via controlled ice crystal growth.
- The approach has been extended from ceramics to aerogels and hydrogels, with a new variant proposed in 2024.
Source: nature.com — Ong, 2026-10-14
Published there as: “Hydrogels and MRI: meet three biomedical engineers reshaping health care”
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