A new era in cancer therapies is at hand

In 2012, clinicians at the Children’s Hospital of Philadelphia treated Emily Whitehead, a 6-year-old with leukemia, with altered immune cells from her own body. At the time, the treatment was experimental, but it worked: The cells targeted the cancer and eradicated it. Thirteen years later, Whitehead is still cancer-free. The modified cells, called CAR-T cells, are a form of immunotherapy, where doctors change parts of the immune system into cancer-attacking instruments. About five years after Whitehead’s treatment, the first CAR-T drugs were approved by the FDA and were heralded, along with immunotherapy more broadly, as one of the most promising modern cancer treatments. Today, there are seven FDA-approved CAR-T therapies, including the one used to treat Whitehead. Since then, however, studies have linked CAR-T to fatal complications due to treatment toxicity, and the treatment has had a harder time addressing certain types of cancers, particularly solid tumors affecting the breast ... Read full article.