Published on: 2025-06-01 22:13:35
“Those chemical modifications that decorate [histones] and modify gene expression — they’re metabolites, full stop,” said Finley, the cancer biologist. “Chemical modifications themselves are metabolites, and their removal is dependent on metabolites.” Fifteen years ago, when Kathryn Wellen was a postdoc studying cancer cells, she discovered that the epigenetic marks on histones change in response to the presence of nutrients. When food is plentiful, mitochondria make a metabolite called acetyl-
Keywords: activity cells genes metabolic nucleus
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