When to watch Arizona Cardinals vs. San Francisco 49ers
Sunday, Sept. 21 at 4:25 p.m. ET (1:25 p.m. PT).
Where to watch
The Cardinals and 49ers game will air on Fox, with Adam Amin and Mark Sanchez on the call.
It's a battle of 2-0 NFC West teams in San Francisco this afternoon. The Cardinals may have won both of their games, but they weren't the most impressive wins: one-score victories over the Saints and Panthers, two of the worst teams in the NFL this season.
I'd say the 49ers will be a truer test for Kyler Murray and the Cardinals, but they'll be starting backup QB Mac Jones for the second straight week. In Brock Purdy's absence last week, however, Jones passed for nearly 300 yards and three TDs. Then again, it was against the sad-sack Saints. We'll know more about each team and its chances in the NFC West after today.
The Cards and Niners kick off at 1:25 p.m. PT (4:25 p.m. ET) on Fox. Here's how you can watch or stream it live, even if the game isn't available on your local Fox channel.
The game will be shown on TV in the Phoenix and San Francisco areas (according to 506 Sports) and on live TV streaming services, but there may be cases where you're blocked because of an internet location glitch. But there's an option that doesn't require subscribing to something like NFL Sunday Ticket or NFL Plus or searching the internet for a sketchy website: You can use a virtual private network.
Here's how you can watch the game from anywhere in the US with a VPN.
Read more: How to Watch NFL Games Without Cable in 2025
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