GoKawiilAbnormal beating of airway cilia from a child with Primary Ciliary Dyskinesia, a genetic disorder affecting respiratory function. Credit: Ning Xu, Tsinghua University Abnormal beating of airway cilia from a child with Primary Ciliary Dyskinesia, a genetic disorder affecting respiratory function. Credit: Ning Xu, Tsinghua University
A Chinese optical engineer is the winner of this year’s Small World in Motion competition, sponsored by Nikon. Ning Xu of Tsinghua University in Beijing beat out 346 other video entries from 40 different countries with his super-resolution video (above) of the abnormal beating of cilia in the airways of a child with a rare genetic respiratory disorder.
Founded in 2011, the Nikon Small World in Motion competition is a spinoff of the company’s Small World Photomicrography Competition, which has been around since 1974. Both are meant “to showcase the beauty and complexity of things seen through the light microscope”—one through still photographs, the other through photovideography, taking advantage of all the technological advances that now allow users to make movies or time-lapse images through the microscope.
Primary ciliary dyskinesia (PCD) is a genetic disorder that adversely affects the tiny hairlike structures that line the lungs, among other areas. Their wavelike motion helps move around germs, mucus, dust, and other irritants so the body can dispel them via coughing or sneezing. In people born with PCD, there is something wrong with those cilia, so those irritants build up, causing respiratory infections, among other complications. The cilia might be the wrong size, the wrong shape, or missing altogether. They might move abnormally, or not move at all.