GoKawiilStudy identifies transcription pause and elongation factors as regulators of antibody hypermutation
Researchers studied how somatic hypermutation, the process that diversifies antibody genes in B cells, is controlled by proteins that regulate RNA polymerase pausing and elongation, including NELF and the Integrator complex subunit INTS8. Using mouse models with Nelfb deleted specifically in germinal center B cells, alongside Ramos and CH12F3 B-cell lines, they mapped how these transcriptional regulators influence mutation patterns in immunoglobulin genes.