GoKawiilZebrafish study ties 5-oxoETE lipid to gut epithelial damage sensing
Researchers used zebrafish larvae, including alox5a and hcar1-4 mutant lines, to study how a lipid signaling molecule called 5-oxoETE helps cells detect epithelial injury and recover from it. They examined wound healing in fin amputation assays and chemical colitis induced by DSS in the larval intestine, tracking leukocyte recruitment and apoptosis across genetic backgrounds. The work was conducted under institutional animal care oversight at Memorial Sloan Kettering Cancer Center.