Researchers propose that Alzheimer's disease progresses through distinct molecular and cellular phases marked by biological thresholds, rather than a simple straight-line path from amyloid buildup to Tau pathology to neurodegeneration. At these thresholds, cells lose homeostatic balance and shift behavior, with these altered states spreading unevenly across brain tissue and eventually reaching regions critical to cognition. A key threshold identified is when amyloid triggers Tau phosphorylation, marking the transition from amyloid-driven tissue states to ones dominated by neuronal stress responses.
nature.com
· 2026-09-16
Scientists at the Salk Institute and collaborators combined multiple detection techniques to identify over 4,300 previously unrecognized 'microproteins' in postmortem brain tissue from the dorsolateral prefrontal cortex, comparing samples from people with and without Alzheimer's disease. Dozens of these tiny proteins, each under 150 amino acids, showed altered levels in Alzheimer's patients, and the findings were published in Nature Aging on September 14.
nature.com
· 2026-09-16
A scientist who has logged 10,000 papers in a reference manager over 13 years describes moving from trying to read every paper closely to a selective, task-driven approach to the literature. The piece also warns that AI tools like ChatGPT, despite improved search and summarization, still risk producing uncritical or fabricated citations if used without careful reading.
nature.com
· 2026-09-01
Researchers at KAIST and the Institute for Basic Science, using APP/PS1 and 5×FAD mouse models along with human brain tissue from a Seoul National University Hospital bank, examined the role of the ERBB4 protein in excitatory neurons. Their experiments indicate that abnormal expression of ERBB4 in these neurons contributes to the progression of Alzheimer's disease-related brain changes.
nature.com
· 2026-08-26
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