GoKawiilMouse study maps amygdala-hypothalamus circuit controlling stress response
Researchers at Icahn School of Medicine at Mount Sinai used male and female C57BL/6J and GAD2-IRES-Cre mice to study a neural circuit linking the amygdala to the anterior hypothalamus. Using whole-brain imaging, optogenetic silencing and calcium imaging, they examined how this circuit influences an animal's sensitivity to stress. No sex differences were found in behavioral or neuronal measures, so sex was dropped as a variable in the final analysis.