App Ps1 Mice

KAIST study finds excitatory neuron ERBB4 receptor drives Alzheimer's pathology in mice

Researchers at KAIST and the Institute for Basic Science, using APP/PS1 and 5×FAD mouse models along with human brain tissue from a Seoul National University Hospital bank, examined the role of the ERBB4 protein in excitatory neurons. Their experiments indicate that abnormal expression of ERBB4 in these neurons contributes to the progression of Alzheimer's disease-related brain changes.