GoKawiilStudy identifies MLLT1 and MLLT3 as factors that focus AID onto specific gene loci
Researchers report that the histone-reader proteins MLLT1 and MLLT3 help concentrate the enzyme AID at particular genomic locations in B cells. This targeting mechanism appears to explain how AID achieves locus specificity during processes such as somatic hypermutation, rather than acting broadly across the genome.