GoKawiilSalk researchers catalogue 4,300+ brain microproteins linked to Alzheimer's disease
Scientists at the Salk Institute and collaborators combined multiple detection techniques to identify over 4,300 previously unrecognized 'microproteins' in postmortem brain tissue from the dorsolateral prefrontal cortex, comparing samples from people with and without Alzheimer's disease. Dozens of these tiny proteins, each under 150 amino acids, showed altered levels in Alzheimer's patients, and the findings were published in Nature Aging on September 14.