Broad Institute - GoKawiil

Google DeepMind launches AlphaGenome Atlas mapping all possible DNA mutations

Google DeepMind has released AlphaGenome Atlas, a 1-petabyte database that uses its AlphaGenome AI model to predict the regulatory impact of all roughly 9 billion possible single-letter mutations across the human genome. The Atlas also introduces a scoring system called AVI, which condenses complex coding and non-coding predictions into one number researchers can use to quickly identify which genetic variants deserve closer study.

blog.google · 2026-09-08

Google DeepMind's AlphaGenome Atlas maps predicted effects of every DNA variant

Google DeepMind released AlphaGenome Atlas, a genome-wide dataset predicting the functional consequences of nearly every possible single-letter DNA change. Academic partners, including researchers from the Broad Institute working with the GREGoR Consortium, used the tool's AVI scoring system to identify a previously overlooked variant in the DNM1 gene linked to epileptic encephalopathy, showing it creates a faulty splice site that abnormally extends the resulting protein. The prediction was later confirmed through lab experiments.

deepmind.google · 2026-09-08