GoKawiilPericyte myosin inhibitor R(+)2501 restores capillary blood flow after kidney ischemia in animal study
Researchers found that renal capillary blood flow in animals becomes refractory to restoration by reperfusion alone once artery occlusion exceeds roughly 10-30 minutes, with pericytes remaining constricted even after large-vessel flow resumes. Administering an intravenous bolus of the compound R(+)2501 after occlusion periods of up to 120 minutes rapidly restored red blood cell velocity and flux to healthy levels within about 6 minutes, and in some cases pushed flow above baseline.