GoKawiilStudy finds WEE1 kinase blocks APC/C-CDH1 to drive cell cycle entry into S phase
Researchers used synchronized human cell lines, including hTert-RPE1, MCF7 and KU1919, arrested via contact inhibition or the CDK4/6 inhibitor palbociclib, to study cell cycle regulation. Their experiments indicate that WEE1 kinase activity counteracts the APC/C-CDH1 complex, a ubiquitin ligase that normally restrains cell cycle progression, thereby enabling cells to transition into S phase.