Cell Type - GoKawiil

Study models sampling limits in mouse forebrain lineage-tracing data

Researchers used simulations built from ground-truth clonal lineages to test how partial sampling and varying capture rates affect the ability to reconstruct clonal architecture in the newborn mouse forebrain. They quantified how many recovered multicellular clones are needed to detect all cell types within a lineage and how accurately observed cell-type proportions match the true underlying clone composition.

nature.com · 2026-09-30

CIGMA tool maps how gene expression variants differ across individual cell types

Researchers introduced CIGMA, a statistical method that uses a linear mixed model to separate genetic effects on gene expression into components shared across cell types and components specific to individual cell types, applied to single-cell RNA sequencing data. The model uses cell-type-level pseudobulk expression averaged from single-cell data, requiring more than 10 cells per individual per cell type, and explicitly accounts for cell-to-cell noise within each individual and cell type.

nature.com · 2026-08-26