GoKawiilMouse study links Pla2g2f enzyme to preserved memory in old age
Researchers at Massachusetts General Hospital found that a phospholipase enzyme called Pla2g2f rises with age in mouse hippocampal cells and is associated with lower brain inflammation and healthier neuron connections. Mice engineered to lack the gene showed increased inflammation and neuron degradation with age, while mice with excess amounts had less inflammation and performed better on spatial memory tests. The findings, published October 15 in Nature Neuroscience, also drew on human and cell-based data.