GoKawiilStudy finds osteoclasts block meningeal lymphatic routes to enable dural tumour spread
Researchers using mouse models traced osteoclast-lineage cells (tdTomato+, CtskCre) in bone marrow and dura mater tissue, comparing their marker expression to invading tumour cells. Using confocal imaging and single-cell RNA sequencing, they characterized osteoclasts and infiltrating tumour cells (ITCs) for markers including DLX5, SCX, TNMD, RUNX2 and COL1A1, showing these cells intersect with meningeal lymphatic structures during dural metastasis.