Whole-body imaging maps cellular activity across every organ in live fish
Researchers developed a light-sheet microscopy method capable of recording cellular-level activity simultaneously across all organs in larval zebrafish and the small, transparent adult fish species Danionella cerebrum. Using carefully controlled husbandry and automated analysis pipelines, the team was able to track physiological signals body-wide rather than in a single organ, revealing coordinated circuits linking the brain to peripheral tissues.