GoKawiil
Tech News
Arizona State University researchers analyzed DNA methylation data from 864 dogs collected through the Dog Aging Project and published their findings in Science. They found that aging correlates with declining epigenetic regulation of transposable DNA sequences called 'jumping genes,' particularly a class known as LINE1s, with giant breeds losing roughly 35 percent of this regulatory control.
Researchers at University Hospital Bonn and the University of Bonn used a virus to deliver two transcription factors, directly converting red blood cell precursors into neural stem cells without passing through a pluripotent stage. Using DNA methylation and RNA sequencing to track changes, they found the converted cells' epigenetic age fell dramatically over 50 to 100 days, reaching roughly 5 percent of the donor's original age. The team published the findings in the journal Aging Cell.
A new bioRxiv preprint analysed DNA methylation patterns in transplanted human hearts and found that, months after surgery, the tissue's biological age markers shifted to resemble the recipient's age rather than the donor's. Researchers observed this effect in both directions: young hearts placed in older bodies appeared to age faster, while older hearts in younger bodies appeared to grow biologically younger.