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Google's fruit fly brain map gets repurposed to play Doom, Mario 64

Google Research and HHMI Janelia released MaleCNS v1.0, a dataset mapping over 166,000 neurons from a male fruit fly's brain and nervous system, built by converting millions of 2D images into 3D neural reconstructions. Developers quickly began using the model outside its intended scientific purpose, wiring its simulated neurons to control games like Doom and Super Mario 64, where sensory input from game frames drives neural activity that translates into player actions.

Fruit Fly Brain Map Used to Simulate Video Game Play

Scientists completed a full map of a male fruit fly's nervous system, detailing its neurons and connections. Programmers have since used this neural map to build simulations that let a virtual version of the fly's brain attempt to play games like Doom and Super Mario 64.

Google's full fruit fly brain map gets put to work playing Doom and Mario 64

Google Research, working with HHMI Janelia Research Campus, published the first complete map of an adult male fruit fly's brain and central nervous system, called MaleCNS v1.0. The AI-assisted project stitched together millions of 2D images into a 3D model reconstructing more than 166,000 neurons. Within days, software engineers used the connectome data to train a simulated version of the fly's neural circuitry to play Doom and Super Mario 64.

San Francisco's Market Street empties out after car ban, crime wave and remote work shift

Market Street, once San Francisco's bustling commercial core, has become a largely deserted stretch lined with boarded-up storefronts and a barren, car-free roadway used mainly by buses. The decline followed the city's 2019 decision to ban private vehicles from the street, compounded by a wave of pandemic-era crime and looting and the mass shift to remote work that emptied downtown offices. Because San Francisco's downtown is zoned mostly for offices rather than housing, the pandemic-driven exodus left the area far emptier than mixed-use downtowns common in Europe and Asia.