Study links fly egg-yolk protein Lsp2 to lifespan effects of early diet
Researchers using Drosophila melanogaster generated a new fly line, Lsp2-muGFP, via CRISPR-Cas9 to track the storage protein Lsp2, alongside RNAi knockdown lines targeting Lsp2 and related genes. The experiments used tissue-specific and stage-specific gene drivers to study how larval nutrition influences protein translation and lifespan in adult flies.