GoKawiilPsychAD study builds cell-type gene expression models from over 6 million brain nuclei
Researchers from the PsychAD consortium describe training single-nucleus transcriptomic imputation models (snTIMs) using single-nucleus RNA sequencing data from more than 6 million nuclei drawn from brain tissue of 1,494 donors. The work involved dividing donors into ancestry groups, harmonizing genotype data across multiple sequencing and array platforms, and building ancestry-specific reference panels to align training and target cohorts, including data from the Million Veteran Program.