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Study finds sex differences in skin stem cell behavior driven by sex chromosomes and hormones

Researchers used multiple transgenic mouse models, including four core genotype (FCG) mice that separate chromosomal sex from gonadal sex, to study epidermal stem cells. By combining lineage tracing tools with castration, ovariectomy and hormone replacement experiments, they examined how sex affects stem cell dynamics in skin.

nature.com · 2026-10-14

Engineered E. coli Ribo-T ribosomes shown to translate proteins from their own rRNA

Researchers modified the tethered Ribo-T ribosome system in E. coli by appending open reading frames for GFP, DFR and HiBiT directly onto the 3′ end of 16S rRNA, creating 'Ribo-TM' constructs. Gel electrophoresis and RT-PCR confirmed the fused mRNA-rRNA molecules were intact and correctly assembled inside functioning ribosomes, and growth assays with mutant ribosomal subunits helped verify that translation activity depended on a functional ribosome.

nature.com · 2026-09-02