GoKawiilResearchers use AlphaFold database to identify TM184C as a GPCR-like regulator
A research team mined all 214.5 million structure predictions in Google DeepMind's AlphaFold database to search for undiscovered 7TM (seven-transmembrane) folds resembling G-protein-coupled receptors. Using the rhodopsin structure as a reference and the TM-align algorithm, they identified TM184C as a previously unrecognized GPCR-like protein involved in regulating cell-to-cell exchange and autophagy. The analysis required processing 24 tebibytes of compressed structural data on university supercomputing clusters.