Gpcr - GoKawiil

Researchers engineer bispecific antibodies that degrade GPCRs to block their signaling

Scientists built bispecific antibody constructs that link cell-surface receptors such as AT1R, APJ, A2AR and CCR6 to transferrin receptor 1, redirecting the GPCRs into internalization and degradation pathways. The constructs, described through detailed plasmid and vector engineering, used nanobody and scFv binding domains along with modified antibody Fc regions to test this trafficking-based antagonism approach in cell-based reporter assays.

nature.com · 2026-09-30

Researchers use AlphaFold database to identify TM184C as a GPCR-like regulator

A research team mined all 214.5 million structure predictions in Google DeepMind's AlphaFold database to search for undiscovered 7TM (seven-transmembrane) folds resembling G-protein-coupled receptors. Using the rhodopsin structure as a reference and the TM-align algorithm, they identified TM184C as a previously unrecognized GPCR-like protein involved in regulating cell-to-cell exchange and autophagy. The analysis required processing 24 tebibytes of compressed structural data on university supercomputing clusters.

nature.com · 2026-09-09