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Study maps 'proximity antigens' on tumor cell surfaces using AI-guided graph learning

Researchers cultured dozens of cancer cell lines alongside normal primary epithelial cells to profile surface proteins near known tumor markers. They applied a graph-learning computational method to identify 'proximity antigens'—proteins located near established cancer targets on the cell membrane—that could serve as new markers for tumor-specific therapies. The work combined wet-lab cell culture across breast, lung, colon, pancreatic, gastric and other cancer types with a novel AI-driven proximity mapping approach.