Gut Brain Axis - GoKawiil

Alzheimer's brains yield over 1,000 unrecognized 'microproteins'

Researchers analyzed human brain tissue samples from people with and without Alzheimer's disease and identified more than 1,000 microproteins that had previously gone undetected. Dozens of these small proteins showed different expression levels in Alzheimer's-affected brains compared with healthy ones. Separately, a mouse study found that immune cells activated by gut infections can travel to the brain's protective membrane and remain there as a lasting defensive memory.

nature.com · 2026-09-16

Gut infections in mice train immune memory cells that settle in brain's protective lining

A mouse study led by Cambridge researcher Menna Clatworthy found that immune cells activated during intestinal infections, such as those caused by Citrobacter rodentium bacteria and the parasitic worm Schistosoma mansoni, travel to the meninges surrounding the brain. There, the cells take up long-term residence and mount a faster, stronger response when the same infection recurs more than a month later, indicating they retain a memory of the original illness.

nature.com · 2026-09-15