GoKawiilCohesin complex found to remodel DNA contacts at stalled replication forks
Researchers using engineered HCT116 cell lines with degradable cohesin components (RAD21, WAPL, CTCF) and SMARCAL1 showed that cohesin actively reorganizes chromatin contacts around replication forks. This reshaping helps slow down forks and promotes their reversal when replication stress occurs, linking genome organization machinery directly to DNA replication control.