CAR-T Cell Therapy Clears Child's Metastatic Liver Cancer in Trial
A young boy with hepatoblastoma that had spread to his lungs and stopped responding to chemotherapy achieved complete remission after receiving an experimental CAR-T cell treatment. The therapy, part of the CARE study, engineered the patient's own immune cells to target glypican-3, a protein found on liver cancer cells, while also boosting the cells' potency with two added immune signaling proteins. Twelve months after treatment, doctors report no detectable trace of the cancer.