GoKawiilQuanta Magazine: AI gene-regulation models like Evo 2, Genos and AlphaGenome still fall short of explaining the genome
A Quanta Magazine report reviews decades of genome research since the 1950s discovery of DNA's structure, noting that the Human Genome Project found only about 2% of human DNA encodes genes. The bulk of the mystery now lies in gene regulation—how genes are switched on and off—and researchers are turning to AI 'foundation models' such as Evo 2, Genos and Google DeepMind's AlphaGenome to help predict how DNA sequence changes affect biology.